Removal and persistence of SCE-inducing damage in human lymphocytes in vitro.


The SCE frequency was studied in PHA-stimulated human lymphocytes exposed to various SCE-inducing agents in different stages of the cell cycle. Melphalan, HN2, MMS, and UV light were found to induce a higher SCE frequency in late G1 (18-24 hr after PHA stimulation) than in early G1 (1-6 hr after PHA) or G0 (before PHA stimulation). In contrast, CCNU induced… (More)


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