Remote preconditioning provides potent cardioprotection via PI3K/Akt activation and is associated with nuclear accumulation of β-catenin.

Abstract

rIPC [remote IPC (ischaemic preconditioning)] has been shown to invoke potent myocardial protection in animal studies and recent clinical trials. Although the important role of PI3K (phosphoinositide 3-kinase)/Akt activation in the cardioprotection afforded by local IPC is well described, our understanding of the intracellular signalling of rIPC remains… (More)
DOI: 10.1042/CS20100466

Topics

6 Figures and Tables

Cite this paper

@article{Li2011RemotePP, title={Remote preconditioning provides potent cardioprotection via PI3K/Akt activation and is associated with nuclear accumulation of β-catenin.}, author={Jing Li and Wanli Xuan and Ran Yan and M. B. Tropak and Emilie Jean-St-Michel and Wenbin Liang and Rachel A. Gladstone and Peter Backx and Rajesh K. Kharbanda and Andrew N Redington}, journal={Clinical science}, year={2011}, volume={120 10}, pages={451-62} }