Remote loading of doxorubicin into liposomes driven by a transmembrane phosphate gradient.

@article{Fritze2006RemoteLO,
  title={Remote loading of doxorubicin into liposomes driven by a transmembrane phosphate gradient.},
  author={Andreas Fritze and Felicitas Hens and Andrea Kimpfler and Rolf Schubert and Regine Peschka-S{\"u}ss},
  journal={Biochimica et biophysica acta},
  year={2006},
  volume={1758 10},
  pages={
          1633-40
        }
}
This study examines a new method for the remote loading of doxorubicin into liposomes. It was shown that doxorubicin can be loaded to a level of up to 98% into large unilamellar vesicles composed of egg phosphatidylcholine/cholesterol (7/3 mol/mol) with a transmembrane phosphate gradient. The different encapsulation efficiencies which were achieved with ammonium salts (citrate 100%, phosphate 98%, sulfate 95%, acetate 77%) were significantly higher as compared to the loading via sodium salts… CONTINUE READING

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