Remote ischemic preconditioning mitigates myocardial and neurological dysfunction via K(ATP) channel activation in a rat model of hemorrhagic shock.

@article{Hu2014RemoteIP,
  title={Remote ischemic preconditioning mitigates myocardial and neurological dysfunction via K(ATP) channel activation in a rat model of hemorrhagic shock.},
  author={Xianwen Hu and Zhengfei Yang and Min Yang and Jie Qian and Jena Cahoon and Jiefeng Xu and Shijie Sun and Wanchun Tang},
  journal={Shock},
  year={2014},
  volume={42 3},
  pages={228-33}
}
Severe hemorrhagic shock and resuscitation is a state of global body ischemia and reperfusion that causes myocardial and cerebral dysfunction. We investigated whether remote ischemic preconditioning (RIPC) would reduce myocardial and cerebral ischemia and reperfusion injuries after hemorrhagic shock as the result of the K(ATP) channel activation. Twenty-one male rats were randomized into three groups: RIPC, RIPC with K(ATP) channel blocker, and control. Remote ischemic preconditioning was… CONTINUE READING
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