Remote homologue identification of Drosophila GAGA factor in mouse

  title={Remote homologue identification of Drosophila GAGA factor in mouse},
  author={Suresh Kumar},
  pages={29 - 32}
GAGA factor (GAF) is involved in both gene activation and gene repression and plays a role in the modulation of chromatin structure. In Drosophila, Trithroax like (Trl) gene encodes the DNA binding protein called GAGA factor (GAF). Trl-GAF binds to GAGA sites through its C2H2 zinc finger domain and has an N-terminal BTB/POZ domain. Identification of Trl-GAF homologue in mouse helps in deeper understanding of the mechanism and function. Conventional alignment tools such as BLAST and FASTA cannot… Expand
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