Remote control of induced dopaminergic neurons in parkinsonian rats.

  title={Remote control of induced dopaminergic neurons in parkinsonian rats.},
  author={Maria Teresa Dell'anno and Massimiliano Caiazzo and Damiana Leo and Elena Dvoretskova and Lucian Medrihan and Gaia Colasante and Serena Giannelli and Ilda Theka and Giovanni Russo and Liudmila V Mus and Gianni Pezzoli and Raul R Gainetdinov and Fabio Benfenati and Stefano Taverna and Alexander E. Dityatev and Vania Broccoli},
  journal={The Journal of clinical investigation},
  volume={124 7},
Direct lineage reprogramming through genetic-based strategies enables the conversion of differentiated somatic cells into functional neurons and distinct neuronal subtypes. Induced dopaminergic (iDA) neurons can be generated by direct conversion of skin fibroblasts; however, their in vivo phenotypic and functional properties remain incompletely understood, leaving their impact on Parkinson's disease (PD) cell therapy and modeling uncertain. Here, we determined that iDA neurons retain a… CONTINUE READING
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