Remote Ischemic Conditioning in Emergency Medicine-Clinical Frontiers and Research Opportunities.

  title={Remote Ischemic Conditioning in Emergency Medicine-Clinical Frontiers and Research Opportunities.},
  author={Andrew Fu Wah Ho and Chong Jun and Marcus Eng Hock Ong and Derek J. Hausenloy},
Time-critical acute ischemic conditions such as ST-elevation myocardial infarction and acute ischemic stroke are staples in Emergency Medicine practice. While timely reperfusion therapy is a priority, the resultant acute ischemia/reperfusion injury contributes to significant mortality and morbidity. Among therapeutics targeting ischemia/reperfusion injury (IRI), remote ischemic conditioning (RIC) has emerged as the most promising.RIC, which consists of repetitive inflation and deflation of a… Expand
Remote Ischemic Conditioning in Ischemic Stroke and Myocardial Infarction: Similarities and Differences
Evidence that RIC reduces circulating biomarkers of myocardial necrosis, infarct size, and edema, although this effect appears not to translate into a better prognosis, is reported. Expand
Effects of remote ischemic conditioning on microcirculatory alterations in patients with sepsis: a single-arm clinical trial
In patients with sepsis, the first remote ischemic conditioning procedure improved microcirculatory flow, whereas later procedures did not affect sublingual microcirculation. Expand
Effect of remote ischemic preConditioning on liver injury in patients undergoing liver resection: the ERIC-LIVER trial.
  • J. Teo, A. Ho, +15 authors D. Hausenloy
  • Medicine
  • HPB : the official journal of the International Hepato Pancreato Biliary Association
  • 2020
This RCT did not demonstrate beneficial effects with RIPC on serum ALT levels 24 h after partial hepatectomy, and no novel hepatoprotective strategies are needed to improve clinical outcomes during liver surgery. Expand
IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST Action
An in vivo set of step-by-step criteria for IM proving P reclinical A ssessment of C ardioprotective T herapies (‘IMPACT’), for investigators to consider adopting before embarking on clinical studies, to improve the likelihood of translating novel cardioprotective interventions into the clinical setting for patient benefit. Expand
What's New in Shock, March 2020?
The 2020 March edition of SHOCK features three excellent review articles, and four clinical reports and seven basic science reports that cover a range of topic to include sepsis, myocardialExpand
Remote Ischemic Conditioning in Acute Myocardial Infarction – Implications of the CONDI-2/ERIC-PPCI Trial for Prehospital and Emergency Medicine
  • A. Ho, M. Ong
  • Medicine
  • Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors
  • 2020
The findings of the CONDI-2/ERIC-PPCI trial are discussed in the context of the existing literature on the topic, and the implications for prehospital and Emergency Medicine in terms of clinical practice and research relating to ischemic conditioning are discussed. Expand
Regulation of STAT3 and its role in cardioprotection by conditioning: focus on non-genomic roles targeting mitochondrial function
Evidence that places STAT3 as a promoter of the metabolic network is highlighted, which focuses on the possible interactions of STAT3 with processes aimed at maintaining mitochondrial functions, including the regulation of the electron transport chain. Expand


Limb Remote Ischemic Conditioning: Mechanisms, Anesthetics, and the Potential for Expanding Therapeutic Options
A comprehensive look at the differences in the three types of RIC (remote pre-, per-, and postconditioning) in acute ischemic stroke. Expand
Remote Ischemic Conditioning in Cerebral Diseases and Neurointerventional Procedures: Recent Research Progress
The aims of this article are to summarize the potential mechanisms underlying different forms of conditioning, to explore the current translation of this paradigm from laboratory to neurovascular diseases, and to outline applications for patient care. Expand
Remote ischemic conditioning in ST-segment elevation myocardial infarction - an update.
The results of the ongoing CONDI2/ERIC-PPCI trial are eagerly awaited, and will provide definitive answers with regards to the cardioprotective effect and clinical outcome benefits of RIC in STEMI. Expand
Peripheral vascular disease as remote ischemic preconditioning, for acute stroke
Chronic limb hypoperfusion induced by PVD can potentially produce a neuroprotective effect in acute ischemic stroke, and this effect resembles the neuroprotection induced by RIPC in preclinical models. Expand
Secondary brain injury in trauma patients: The effects of remote ischemic conditioning
This study showed that RIC significantly decreased the standard biomarkers of acute brain injury in patients with severe TBI, highlighting the novel therapeutic role of RIC for preventing secondary brain insults in TBI patients. Expand
Remote ischemic conditioning.
Remote ischemic conditioning by repeated brief inflation/deflation of a blood pressure cuff protects against endothelial dysfunction and myocardial injury in percutaneous coronary interventions, coronary artery bypass grafting, and reperfused acuteMyocardial infarction. Expand
Phase I clinical trial for the feasibility and safety of remote ischemic conditioning for aneurysmal subarachnoid hemorrhage.
The RIC procedure was well tolerated and did not cause any injury, and warrants investigation in a subsequent pivotal clinical trial. Expand
Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations
There remains an urgent need to discover novel therapies which can be given prior to or at the time of PPCI to reduce myocardial infarct (MI) size in order to preserve left ventricular (LV) systolic function, prevent the onset of heart failure, and improve survival in reperfused STEMI patients. Expand
Remote ischemic conditioning reduces myocardial infarct size and edema in patients with ST-segment elevation myocardial infarction.
This randomized study demonstrated that in ST-segment elevation myocardial infarction patients treated by PPCi, RIC, initiated prior to PPCI, reduced MI size, increased myocardian salvage, and reduced myocardia edema. Expand
Remote Ischemic Perconditioning as an Adjunct Therapy to Thrombolysis in Patients With Acute Ischemic Stroke: A Randomized Trial
A tissue survival analysis suggests that prehospital rPerC may have immediate neuroprotective effects and future clinical trials should take such immediate effects, and their duration, into account. Expand