Remote Activation of Host Cell DNA Synthesis in Uninfected Cells Signaled by Infected Cells in Advance of Virus Transmission

@inproceedings{Schmidt2015RemoteAO,
  title={Remote Activation of Host Cell DNA Synthesis in Uninfected Cells Signaled by Infected Cells in Advance of Virus Transmission},
  author={Nora Schmidt and Thomas Hennig and Remigiusz A. Serwa and Magda Marchetti and Peter O'Hare},
  booktitle={Journal of virology},
  year={2015}
}
UNLABELLED Viruses modulate cellular processes and metabolism in diverse ways, but these are almost universally studied in the infected cell itself. Here, we study spatial organization of DNA synthesis during multiround transmission of herpes simplex virus (HSV) using pulse-labeling with ethynyl nucleotides and cycloaddition of azide fluorophores. We report… CONTINUE READING