Remodelling of human osteoarthritic cartilage by FGF‐2, alone or combined with Sox9 via rAAV gene transfer

@article{Cucchiarini2009RemodellingOH,
  title={Remodelling of human osteoarthritic cartilage by FGF‐2, alone or combined with Sox9 via rAAV gene transfer},
  author={M. Cucchiarini and E. Terwilliger and D. Kohn and H. Madry},
  journal={Journal of Cellular and Molecular Medicine},
  year={2009},
  volume={13}
}
  • M. Cucchiarini, E. Terwilliger, +1 author H. Madry
  • Published 2009
  • Chemistry, Medicine
  • Journal of Cellular and Molecular Medicine
  • Compensating for the loss of extracellular cartilage matrix, as well as counteracting the alterations of the chondrocyte phenotype in osteoarthritis are of key importance to develop effective therapeutic strategies against this disorder. In the present study, we analysed the benefits of applying a potent gene combination to remodel human osteoarthritic (OA) cartilage. We employed the promising recombinant adeno‐associated virus (rAAV) vector to deliver the mitogenic fibroblast growth factor 2… CONTINUE READING
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    References

    SHOWING 1-10 OF 68 REFERENCES
    Improved tissue repair in articular cartilage defects in vivo by rAAV-mediated overexpression of human fibroblast growth factor 2.
    • 133
    Cartilage, SOX9 and Notch signals in chondrogenesis
    • 110
    Enhanced matrix synthesis and in vitro formation of cartilage‐like tissue by genetically modified chondrocytes expressing BMP‐7
    • 67
    • Highly Influential
    Resurfacing of articular cartilage explants with genetically-modified human chondrocytes in vitro.
    • 73