Remodelling of human osteoarthritic cartilage by FGF-2, alone or combined with Sox9 via rAAV gene transfer.

@article{Cucchiarini2009RemodellingOH,
  title={Remodelling of human osteoarthritic cartilage by FGF-2, alone or combined with Sox9 via rAAV gene transfer.},
  author={Magali Cucchiarini and Ernest F. Terwilliger and Dieter Kohn and Henning Madry},
  journal={Journal of cellular and molecular medicine},
  year={2009},
  volume={13 8B},
  pages={
          2476-88
        }
}
Compensating for the loss of extracellular cartilage matrix, as well as counteracting the alterations of the chondrocyte phenotype in osteoarthritis are of key importance to develop effective therapeutic strategies against this disorder. In the present study, we analysed the benefits of applying a potent gene combination to remodel human osteoarthritic (OA) cartilage. We employed the promising recombinant adeno-associated virus (rAAV) vector to deliver the mitogenic fibroblast growth factor 2… CONTINUE READING

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