Remodelling of human osteoarthritic cartilage by FGF‐2, alone or combined with Sox9 via rAAV gene transfer

  title={Remodelling of human osteoarthritic cartilage by FGF‐2, alone or combined with Sox9 via rAAV gene transfer},
  author={M. Cucchiarini and E. Terwilliger and D. Kohn and H. Madry},
  journal={Journal of Cellular and Molecular Medicine},
  • M. Cucchiarini, E. Terwilliger, +1 author H. Madry
  • Published 2009
  • Chemistry, Medicine
  • Journal of Cellular and Molecular Medicine
  • Compensating for the loss of extracellular cartilage matrix, as well as counteracting the alterations of the chondrocyte phenotype in osteoarthritis are of key importance to develop effective therapeutic strategies against this disorder. In the present study, we analysed the benefits of applying a potent gene combination to remodel human osteoarthritic (OA) cartilage. We employed the promising recombinant adeno‐associated virus (rAAV) vector to deliver the mitogenic fibroblast growth factor 2… CONTINUE READING
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