Remodeling of the airway smooth muscle cell: are we built of glass?

  title={Remodeling of the airway smooth muscle cell: are we built of glass?},
  author={Ben Fabry and Jeffrey J. Fredberg},
  journal={Respiratory physiology & neurobiology},
  volume={137 2-3},
Classical understanding of airway lumen narrowing in asthma has held that the isometric force generated by airway smooth muscle (ASM) must be at every instant in a static mechanical equilibrium with the external load against which the muscle has shortened. It has been established recently, however, that this balance of static forces does not apply in the setting of tidal loading as occurs during breathing and must give way to the broader concepts of (1). the perturbed contractile state that… CONTINUE READING


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