Remodeling of the Methylation Landscape in Breast Cancer Metastasis

Abstract

The development of breast cancer metastasis is accompanied by dynamic transcriptome changes and dramatic alterations in nuclear and chromatin structure. The basis of these changes is incompletely understood. The DNA methylome of primary breast cancers contribute to transcriptomic heterogeneity and different metastatic behavior. Therefore we sought to… (More)
DOI: 10.1371/journal.pone.0103896

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