Remodeling of phospholipid composition in colon cancer cells by 1α,25(OH)2D3 and its analogs

  title={Remodeling of phospholipid composition in colon cancer cells by 1$\alpha$,25(OH)2D3 and its analogs},
  author={Carlien Leyssens and Eyra Marien and Lieve Verlinden and Rita Derua and Etienne Waelkens and Johannes V. Swinnen and Annemieke Verstuyf},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
Vitamin D regulation of energy metabolism in cancer
Mechanisms involved in energy metabolism regulation are an emerging area in which vitamin D may inhibit multiple stages of cancer progression, as well as oxidative stress protection, as it is closely associated with energy metabolism.
Phospholipid profiling enables to discriminate tumor- and non-tumor-derived human colon epithelial cells: Phospholipidome similarities and differences in colon cancer cell lines and in patient-derived cell samples
Identification of changes of phospholipid (PL) composition occurring during colorectal cancer (CRC) development may help us to better understand their roles in CRC cells. Here, we used LC-MS/MS-based
Metabolic alterations in multiple sclerosis and the impact of vitamin D supplementation.
The utility of metabolomics is demonstrated in identifying aberrant metabolic processes and in monitoring the ability of therapeutic interventions to correct these abnormalities in multiple sclerosis patients and healthy controls.
Identification of Vitamin D-related gene signature to predict colorectal cancer prognosis
A novel vitamin D-related gene model is proposed to predict the prognosis of CRC, which will help provide new therapeutic targets and act as potential prognostic biomarkers for CRC.
Comparative Proteomics Uncovers Correlated Signaling Network and Potential Biomarkers for Progression of Prostate Cancer
This study identified 203 differential proteins closely associated with tumor cell migration, and the mRNA expression of those proteins were verified by qPCR and the migration associated molecular network was established using bioinformatics analysis.
Vitamin D ve Antikanserojenik Etkileri
Vitamin D, yagda ve organik cozuculerde cozunen, fakat suda cozunmeyen, sahip oldugu reseptorleri araciligiyla her organ ve dokuya ulasip onemli gorevler yapmasi sebebiyle hormon benzeri gorev yapan
Lipid remodelling in human melanoma cells in response to UVA exposure.
  • E. Maciel, Juliana Felgueiras, M. Domingues
  • Biology, Chemistry
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
  • 2017
Data showed changes in membrane lipids, which may be associated with lipogenesis after UVA exposure which, in turn, is usually a determinant for cell survival, in this study.
Class 3 semaphorins are transcriptionally regulated by 1,25(OH)2D3 in osteoblasts


Antineoplastic effects of 1,25(OH)2D3 and its analogs in breast, prostate and colorectal cancer.
It appears that the epidemiological link between vitamin D3 and cancer is the strongest for CRC, however more intervention studies and randomized placebo-controlled trials are needed to unravel the beneficial dose of 1,25(OH)2D3 and its analogs to induce antineoplastic effects.
Abrogation of De novo Lipogenesis by Stearoyl-CoA Desaturase 1 Inhibition Interferes with Oncogenic Signaling and Blocks Prostate Cancer Progression in Mice
The concept of targeting the lipogenic enzyme SCD1 as a new promising therapeutic approach to block oncogenesis and prostate cancer progression is supported for the first time.
Novel lipogenic enzyme ELOVL7 is involved in prostate cancer growth through saturated long-chain fatty acid metabolism.
The findings suggest that EVOLV7 could be involved in prostate cancer growth and survival through the metabolism of SVLFAs and their derivatives, could be a key molecule to elucidate the association between fat dietary intake and prostate carcinogenesis, and could also be a promising molecular target for development of new therapeutic or preventive strategies for prostate cancers.
The role of phosphatidylcholine and choline metabolites to cell proliferation and survival
  • N. Ridgway
  • Biology, Chemistry
    Critical reviews in biochemistry and molecular biology
  • 2013
Current understanding of how coordinated changes in substrate availability, gene expression and enzyme activity lead to altered phosphatidylcholine synthesis in cancer, and how these changes contribute directly or indirectly to malignant growth are detailed.
Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of β-catenin signaling
1α,25(OH)2D3 induces E-cadherin and modulates β-catenin–TCF-4 target genes in a manner opposite to that of β- catenin, promoting the differentiation of colon carcinoma cells.
The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung.
The results suggested that expression of FASE is an early event in the development and progression of SCC of the lung and the inhibition of fatty acid synthesis by inhibiting enzymatic function with metabolic analogues may be a useful strategy in the treatment of S CCs.
Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma.
Analysis of immunohistochemical expression of FAS and human acetyl-CoA carboxylase in breast cancer progression through the development of in situ duct and lobular carcinoma suggests that expression of the enzymes of fatty acid synthesis are frequently altered early in the progression of human breast carcinoma.