Remodeling of myocyte gap junctions in arrhythmogenic right ventricular cardiomyopathy due to a deletion in plakoglobin (Naxos disease).

@article{Kaplan2004RemodelingOM,
  title={Remodeling of myocyte gap junctions in arrhythmogenic right ventricular cardiomyopathy due to a deletion in plakoglobin (Naxos disease).},
  author={Starr R Kaplan and Joseph J Gard and Nikos I Protonotarios and Adalena A Tsatsopoulou and Chara A. Spiliopoulou and Aris Anastasakis and Catherine Prost Squarcioni and William J. McKenna and Gaetano Thiene and Cristina Basso and Nicole Brousse and Guy Hugues Fontaine and Jeffrey E. Saffitz},
  journal={Heart rhythm},
  year={2004},
  volume={1 1},
  pages={3-11}
}
OBJECTIVES We tested the hypothesis that defective interactions between adhesion junctions and the cytoskeleton caused by the plakoglobin mutation in Naxos disease lead to remodeling of gap junctions and altered expression of the major gap junction protein, connexin43. BACKGROUND Naxos disease, a recessive form of arrhythmogenic right ventricular cardiomyopathy, is associated with a high incidence of arrhythmias and sudden cardiac death. Naxos disease is caused by a mutation in plakoglobin, a… CONTINUE READING

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