Remodeling of intermediate metabolism in the diatom Phaeodactylum tricornutum under nitrogen stress.

@article{Levitan2015RemodelingOI,
  title={Remodeling of intermediate metabolism in the diatom Phaeodactylum tricornutum under nitrogen stress.},
  author={Orly Levitan and Jorge Dinamarca and Ehud Zelzion and Desmond S. Lun and Luis Tiago Marques Guerra and Min Kyung Kim and Joomi Kim and Benjamin A S Van Mooy and Debashish Bhattacharya and Paul G. Falkowski},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 2},
  pages={
          412-7
        }
}
Diatoms are unicellular algae that accumulate significant amounts of triacylglycerols as storage lipids when their growth is limited by nutrients. Using biochemical, physiological, bioinformatics, and reverse genetic approaches, we analyzed how the flux of carbon into lipids is influenced by nitrogen stress in a model diatom, Phaeodactylum tricornutum. Our results reveal that the accumulation of lipids is a consequence of remodeling of intermediate metabolism, especially reactions in the… CONTINUE READING

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