Remodeling of excitation-contraction coupling in transgenic mice expressing ATP-insensitive sarcolemmal KATP channels.

@article{Flagg2004RemodelingOE,
  title={Remodeling of excitation-contraction coupling in transgenic mice expressing ATP-insensitive sarcolemmal KATP channels.},
  author={Thomas P. Flagg and F. Charpentier and Jocelyn E Manning-Fox and Maria S Remedi and Decha Enkvetchakul and Anatoli N. Lopatin and Joseph C. Koster and Colin Nichols},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2004},
  volume={286 4},
  pages={H1361-9}
}
Reducing the ATP sensitivity of the sarcolemmal ATP-sensitive K(+) (K(ATP)) channel is predicted to lead to active channels in normal metabolic conditions and hence cause shortened ventricular action potentials and reduced myocardial inotropy. We generated transgenic (TG) mice that express an ATP-insensitive K(ATP) channel mutant [Kir6.2(deltaN2-30,K185Q)] under transcriptional control of the alpha-myosin heavy chain promoter. Strikingly, myocyte contraction amplitude was increased in TG… CONTINUE READING

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