Remodeling of chromatin structure within the promoter is important for bmp-2-induced fgfr3 expression

@inproceedings{Sun2009RemodelingOC,
  title={Remodeling of chromatin structure within the promoter is important for bmp-2-induced fgfr3 expression},
  author={Fenyong Sun and Qiongyu Chen and Songhai Yang and Qiuhui Pan and Ji Min Ma and Yang Wan and Chih-hao Chang and Andong Hong},
  booktitle={Nucleic acids research},
  year={2009}
}
Fibroblast growth factor receptor 3 (FGFR3) plays an important role in cartilage development. Although upregulation of FGFR3 expression in response to bone morphogenetic protein-2 (BMP-2) has been reported, the molecular mechanisms remain unknown. In this study, we used in vivo approaches to characterize BMP-2-induced alterations in the chromatin organization of the FGFR3 core promoter. Chromatin immunoprecipitation analysis demonstrated that the binding of Brg1, a component of the SWI/SNF… CONTINUE READING

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