Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway

  title={Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway},
  author={Youssef H. Zeidan and Russell William Jenkins and Yusuf A. Hannun},
  journal={The Journal of Cell Biology},
  pages={335 - 350}
The chemotherapeutic agent cisplatin is widely used in treatment of solid tumors. In breast cancer cells, cisplatin produces early and marked changes in cell morphology and the actin cytoskeleton. These changes manifest as loss of lamellipodia/filopodia and appearance of membrane ruffles. Furthermore, cisplatin induces dephosphorylation of the actin-binding protein ezrin, and its relocation from membrane protrusions to the cytosol. Because cisplatin activates acid sphingomyelinase (ASMase), we… CONTINUE READING


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