Remodeling of axo-spinous synapses in the pathophysiology and treatment of depression.

@article{Licznerski2013RemodelingOA,
  title={Remodeling of axo-spinous synapses in the pathophysiology and treatment of depression.},
  author={Pawel Licznerski and Ronald S Duman},
  journal={Neuroscience},
  year={2013},
  volume={251},
  pages={33-50}
}
Dendritic spines provide a compartment for assembly and functional organization of synaptic machinery that plays a fundamental role in neuronal communication and neuroplasticity. Studies in humans as well as in animal models have demonstrated abnormal spine architecture in several psychiatric disorders, including depression and other stress-related illnesses. The negative impact of stress on the density and organization of spines is thought to contribute to the behavioral deficits caused by… CONTINUE READING