Remodeling of DNA replication structures by the branch point translocase FANCM.

Abstract

Fanconi anemia (FA) is a genetically heterogeneous chromosome instability syndrome associated with congenital abnormalities, bone marrow failure, and cancer predisposition. Eight FA proteins form a nuclear core complex, which promotes tolerance of DNA lesions in S phase, but the underlying mechanisms are still elusive. We reported recently that the FA core… (More)
DOI: 10.1073/pnas.0804777105

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