Remodeling nuclear architecture allows efficient transport of herpesvirus capsids by diffusion.

  title={Remodeling nuclear architecture allows efficient transport of herpesvirus capsids by diffusion.},
  author={Jens B Bosse and Ian B Hogue and Marina Feric and Stephan Y. Thiberge and Beate Sodeik and Clifford P Brangwynne and Lynn W Enquist},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={112 42},
The nuclear chromatin structure confines the movement of large macromolecular complexes to interchromatin corrals. Herpesvirus capsids of approximately 125 nm assemble in the nucleoplasm and must reach the nuclear membranes for egress. Previous studies concluded that nuclear herpesvirus capsid motility is active, directed, and based on nuclear filamentous actin, suggesting that large nuclear complexes need metabolic energy to escape nuclear entrapment. However, this hypothesis has recently been… CONTINUE READING
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