Remission of oral leukoplakias and micronuclei in tobacco/betel quid chewers treated with beta‐carotene and with beta‐carotene plus vitamin A

@article{Stich1988RemissionOO,
  title={Remission of oral leukoplakias and micronuclei in tobacco/betel quid chewers treated with beta‐carotene and with beta‐carotene plus vitamin A},
  author={H. Stich and M. Rosin and A. P. Hornby and B. Mathew and R. Sankaranarayanan and M. Nair},
  journal={International Journal of Cancer},
  year={1988},
  volume={42}
}
Fishermen from Kerala (India) who chewed tobacco‐containing betel quids daily (17.2 ± 9.6 quids per day) and had well‐developed oral leukoplakias with elevated frequencies of micronucleated cells participated in a short‐term intervention trial. Beta‐carotene (180 mg/week) (Group I), beta‐carotene (180 mg/week) plus vitamin A (100,000 IU/week) (Group II), and placebo (Group III) capsules were given twice weekly for 6 months under strict supervision. The remission of oral leukoplakias, the… Expand
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The administration of β-carotene plus vitamin A or vitamin A alone to chewers of betel quids in Kerala, India led to a reduction in the frequency of micronucleated buccal mucosal cells, a remission of oral leukoplakia, and an inhibition of the development of newLeukoplakias. Expand
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  • Medicine
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The possibility that in this population an increase in the dietary intake of retinol and/or carotene may reduce the incidence of oral cancer is suggested, which is an important neoplasm in many parts of Asia. Expand
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TLDR
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