Remission of diabetes by insulin gene therapy using a hepatocyte-specific and glucose-responsive synthetic promoter.

@article{Han2011RemissionOD,
  title={Remission of diabetes by insulin gene therapy using a hepatocyte-specific and glucose-responsive synthetic promoter.},
  author={Jaeseok Han and Brienne McLane and Eung-Hwi Kim and Ji-Won Yoon and Hee-Sook Jun},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2011},
  volume={19 3},
  pages={470-8}
}
Efficient production of insulin in response to changes in glucose levels has been a major issue for insulin gene therapy to treat diabetes. To express target genes in response to glucose specifically in hepatocytes, we generated a synthetic promoter library containing hepatocyte nuclear factor-1, CAAT/enhancer-binding protein (C/EBP) response element, and glucose-response element. Combinations of these three cis-elements in 3-, 6-, or 9-element configurations were screened for transcriptional… CONTINUE READING
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