Reminiscences of Sir Peter Medawar: In Hope of Antigen‐Specific Transplantation Tolerance

  title={Reminiscences of Sir Peter Medawar: In Hope of Antigen‐Specific Transplantation Tolerance},
  author={Elizabeth M. Simpson},
  journal={American Journal of Transplantation},
  • E. Simpson
  • Published 2004
  • Medicine
  • American Journal of Transplantation
Peter Medawar's career in medical research (he always described himself as a medical research scientist) began as a student of zoology in Oxford. He obtained a first class degree in 1936, aged 21, and undertook postgraduate studies with Florey. His work was anchored in a broad field; he was adept at addressing novel questions in the context of prior ideas and knowledge. His earlier interest in growth, driven as much by mathematics as biology, gave way to transplantation at the beginning of… Expand
Medawar's legacy to cellular immunology and clinical transplantation: a commentary on Billingham, Brent and Medawar (1956) ‘Quantitative studies on tissue transplantation immunity. III. Actively acquired tolerance’
  • E. Simpson
  • Biology, Medicine
  • Philosophical Transactions of the Royal Society B: Biological Sciences
  • 2015
This work influenced both immunology researchers and clinicians and helped to lay the foundations for successful transplantation programmes, and led to the award of a Nobel prize in 1960 to Medawar, and subsequently to several scientists who advanced these areas. Expand
Nobel Prize Winners Who Contributed To Transplantation.
Alexis Carrel’s success with organ grafts was not dependent on a new method of suturing but on his use of fine needles and suture material, his exceptional technical skill, and his obsession with strict asepsis. Expand
Maternal Leukocytes and Infant Immune Programming during Breastfeeding.
The newest advances on how milk leukocytes impact early life immunity are discussed, with an emphasis on the development of the infant T cell repertoire and early immune responses in the periphery and gut-associated lymphoid tissue. Expand
High-risk cutaneous malignancies and immunosuppression: Challenges for the reconstructive surgeon in the renal transplant population.
Key concepts in the pathogenesis of skin cancer in transplant patients, the impact current and evolving immunosuppressive strategies and regimens will have on the epidemiology, and the management of cutaneous malignancies in renal transplant patients are highlighted, with particular focus on the implications for the plastic surgery community. Expand
Los trasplantes regresan a sus orígenes. A propósito del trasplante de tejidos compuestos
Reviewing the history and future projections of these two specialties, it is found that these branches of modern surgery share not only the same origins but also the same goals. Expand
Las células T reguladoras y su influencia en la sobrevida del trasplante renal
Resumen La respuesta inmune desencadenada frente a un trasplante alogenico conduce usualmente a una respuesta efectora que resulta en el rechazo del aloinjerto; sin embargo, algunos individuosExpand


Landmarks in Immunology
The development of immunology during the course of over a century has been quite breathtaking and it has sustained the intellectual excitement of its formative years in the past two decades of the 19th century. Expand
‘Actively Acquired Tolerance’ of Foreign Cells
The experiments to be described in this article provide a solution—at present only a ‘laboratory’ solution—of the problem of how to make tissue homografts immunologically acceptable to hosts whichExpand
Quantitative Studies on Tissue Transplantation Immunity. III. Actively Acquired Tolerance
Every degree of tolerance is possible, from that which allows a homograft to live only a few days beyond its normal median expectation of survival to that in which it is permanently accepted by and incorporated into its host. Expand
A history of transplantation immunology
The Mammalian Fetus: Natures (Almost) Perfect Allografts and the Interaction Between Immunology, Transplantation, Surgery, and Other Matters. Expand
Quantitative studies on tissue transplantation immunity. IX.* Induction of tolerance with antilymphocytic serum
  • E. Lance, P. Medawar
  • Biology
  • Proceedings of the Royal Society of London. Series B. Biological Sciences
  • 1969
It is argued that differences between conventional and ALS-induced tolerance can be explained in terms of cellular population dynamics. Expand
Anaplasia rediviva.
Modern research rehabilitates an etiologc notion earlier thought to have been discredited, those that are capable of arousing cell-mediated immunity and thus may contribute to antitumor immunity. Expand
Mechanisms of Peripheral Tolerance and Suppression Induced by Monoclonal Antibodies to CD4 and CD8
Recent data that IL-4 plays a role in suppression, but that the source ofIL-4 may not be the tolerant/suppressor T cell is reviewed, and a model of infectious anergy that is compatible with the available data is suggested. Expand
The male-specific histocompatibility antigen, H-Y: a history of transplantation, immune response genes, sex determination and expression cloning.
The Hya/HYA gene(s) encoding H-Y antigen have been mapped using translocations, mutations, and deletions to Yq in humans and to the short arm of the Y chromosome in mice, where they lie in the deletion defined by the Sxrb mutation between Zfy-1 andZfy-2. Expand
Transplantation tolerance induced by intranasal administration of HY peptides.
Hyp peptide-specific CD4(+) and CD8(+) T cells expand on re-exposure to male antigen; these expansions are smaller in tolerant than control mice and fewer HY-specific cells from tolerant females secrete interferon gamma and interleukin 10 (IL-10). Expand
Synergy among lymphoid cells mediating the graft-versus-host response. 3. Evidence for interaction between two types of thymus-derived cells.
Since synergism was also obtained using appropriate mixtures of cells from either parental strain in F(1) hosts, it was possible to show that the nonrecirculating cells determined the specificity of the response and were probably the precursors of effector cells in this response. Expand