Remarkably similar CTLA-4 binding properties of therapeutic ipilimumab and tremelimumab antibodies

@inproceedings{He2017RemarkablySC,
  title={Remarkably similar CTLA-4 binding properties of therapeutic ipilimumab and tremelimumab antibodies},
  author={Mengnan He and Yan Chai and Jianxun Qi and Catherine W.H. Zhang and Zhou Tong and Yi Shi and Jinghua Yan and Shuguang Tan and George F. Gao},
  booktitle={Oncotarget},
  year={2017}
}
Monoclonal antibody based immune checkpoint blockade therapies have achieved clinical successes in management of malignant tumors. As the first monoclonal antibody targeting immune checkpoint molecules entered into clinics, the molecular basis of ipilimumab-based anti-CTLA-4 blockade has not yet been fully understood. In the present study, we report the complex structure of ipilimumab and CTLA-4. The complex structure showed similar contributions from VH and VL of ipilimumab in binding to CTLA… CONTINUE READING
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