Remarkably reduced transplant-related complications by dibromomannitol non-myeloablative conditioning before allogeneic bone marrow transplantation in chronic myeloid leukemia.

Abstract

A non-myeloablative conditioning protocol containing dibromomannitol (DBM/cytosine arabinoside/cyclophosphamide) has been applied to 36 chronic myeloid leukemia (CML) patients followed by bone marrow transplantation (BMT) from sibling donors. Risk factors include: accelerated phase (10 patients), older age (17 patients over >40 years) and long interval between diagnosis and BMT (27 months on average). Severe mucositis did not occur. Venoocclusive liver disease was absent. Infectious complications were rare. Although grade II-IV acute graft-versus-host disease (GVHD) was present in 9 (25%) cases, there were only 2 serious (III-IV) ones. Chronic GVHD occurred in 25 (69%) cases, preceded by acute GVHD in 9 of the 25 affected patients. Early hematological relapse, 7-29 weeks after BMT, developed in 6 patients (17.6%). No relapse was noted in the completely chimeric patients, however molecular genetic residual disease was observed in 6 patients, in most of them after transient short-term mixed chimeric state. Overall actual survival rate is 83.3% for the 36 cases, and leukemia-free survival is 72.2% for the 34 engrafted patients.

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@article{Barta2001RemarkablyRT, title={Remarkably reduced transplant-related complications by dibromomannitol non-myeloablative conditioning before allogeneic bone marrow transplantation in chronic myeloid leukemia.}, author={Anik{\'o} Barta and R{\'e}ka D{\'e}nes and Tamas Masszi and P{\'e}ter Rem{\'e}nyi and {\'A}rp{\'a}d B{\'a}tai and {\'E}va Torb{\'a}gyi and Andrea Sipos and Lilla Lengyel and Kl{\'a}ra Jakab and Eva Gy{\'o}di and Marienn R{\'e}ti and J{\'a}nos F{\"{o}ldi and Piroska P{\'a}ldi-Haris and Matthew J. Avalos and Katalin P{\'a}l{\'o}czi and S{\'a}ndor Gy{\"{o}rgy Fekete and Jozef T{\"{o}r{\"{o}k and Izabella Hoffer and Janka Jakab and G{\'a}bor V{\'a}radi and Eduard Kelemen and G y Petr{\'a}nyi}, journal={Acta haematologica}, year={2001}, volume={105 2}, pages={64-70} }