Remarkably low incidence of hypospadias in Greenland despite high exposure to endocrine disrupters; possible protective effect of androgen receptor genotype.

@article{Giwercman2006RemarkablyLI,
  title={Remarkably low incidence of hypospadias in Greenland despite high exposure to endocrine disrupters; possible protective effect of androgen receptor genotype.},
  author={Yvonne Lundberg Giwercman and Knud Erik Kleist and A Giwercman and Charlotte Giwercman and Gunnar Toft and J. Bonde and Henning Sloth Pedersen},
  journal={Pharmacogenetics and genomics},
  year={2006},
  volume={16 5},
  pages={375-7}
}
Endocrine disrupters, such as persistent organohalogen pollutants (POPs) may cause hypospadias, which is a common congenital anomaly in males, affecting 0.2-0.7%. We hypothesized that hypospadias incidence would be high among Greenlanders, who are one of the most POP exposed populations on earth through consumption of contaminated sea mammals. Interestingly, among the 11 076 boys born in Greenland 1982-2002, only two cases of hypospadias were noted (incidence 0.02%; 95% CI: 0.002-0.06). Normal… CONTINUE READING