Remarkable longevity and stress resistance of nematode PI3K-null mutants.

@article{Ayyadevara2008RemarkableLA,
  title={Remarkable longevity and stress resistance of nematode PI3K-null mutants.},
  author={Srinivas Ayyadevara and Ramani Alla and John J. Thaden and Robert Joseph Shmookler Reis},
  journal={Aging cell},
  year={2008},
  volume={7 1},
  pages={13-22}
}
The great majority of lifespan-augmenting mutations were discovered in the nematode Caenorhabditis elegans. In particular, genetic disruption of insulin-like signaling extends longevity 1.5- to 3-fold in the nematode, and to lesser degrees in other taxa, including fruit flies and mice. C. elegans strains bearing homozygous nonsense mutations in the age-1 gene, which encodes the class-I phosphatidylinositol 3-kinase catalytic subunit (PI3K(CS)), produce progeny that were thought to undergo… CONTINUE READING