Remarkable leukemogenic potency and quality of a constitutively active neurotrophin receptor, ΔTrkA

@article{Meyer2007RemarkableLP,
  title={Remarkable leukemogenic potency and quality of a constitutively active neurotrophin receptor, ΔTrkA},
  author={Johann Conrad Meyer and Mathias Rhein and Bernd Schiedlmeier and Olga Kustikova and Cornelia Rudolph and Kenji Kamino and Thomas E. Neumann and Min Yang and A Nke Wahlers and Boris Fehse and Gary W. Reuther and Brigitte Schlegelberger and Arnold Ganser and Christopher C. Baum and Zaomin Li},
  journal={Leukemia},
  year={2007},
  volume={21},
  pages={2171-2180}
}
Neurotrophins and their receptors play a key role in neurogenesis and survival. However, we and others have recently obtained evidence for a potential involvement of this receptor system in leukemia. To investigate mechanisms underlying the leukemogenic potential of activated neurotrophin receptor signaling, we analyzed in vivo leukemogenesis mediated by ΔTrkA, a mutant of TRKA (tropomyosin-related kinase A) isolated from a patient with acute myeloid leukemia (AML). Retroviral expression of… CONTINUE READING
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