Remarkable increases of α1-antichymotrypsin in brain tissues of rodents during prion infection.

@article{Chen2017RemarkableIO,
  title={Remarkable increases of α1-antichymotrypsin in brain tissues of rodents during prion infection.},
  author={Cao Chen and Xiao-Feng Xu and Ren-Qing Zhang and Yue Ma and Yan Chun Lv and Jian-Le Li and Qiang Shi and Kang Xiao and Jing Sun and Xiao-Dong Yang and Qi Shi and Xiao-Ping Dong},
  journal={Prion},
  year={2017},
  volume={11 5},
  pages={
          338-351
        }
}
α1-Antichymotrypsin (α1-ACT) belongs to a kind of acute-phase inflammatory protein. Recently, such protein has been proved exist in the amyloid deposits which is the hallmark of Alzheimer's disease, but limitedly reported in prion disease. To estimate the change of α1-ACT during prion infection, the levels of α1-ACT in the brain tissues of scrapie agents 263K-, 139A- and ME7-infected rodents were analyzed, respectively. Results shown that α1-ACT levels were significantly increased in the brain… CONTINUE READING
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