Remarkable increase in nuclease resistance of plasmid DNA through supramolecular assembly with poly(ethylene glycol)-poly(L-lysine) block copolymer.

@article{Katayose1998RemarkableII,
  title={Remarkable increase in nuclease resistance of plasmid DNA through supramolecular assembly with poly(ethylene glycol)-poly(L-lysine) block copolymer.},
  author={Satoshi Katayose and Kazunori Kataoka},
  journal={Journal of pharmaceutical sciences},
  year={1998},
  volume={87 2},
  pages={160-3}
}
Supramolecular associates of DNA with Poly(ethylene glycol)-poly(L-lysine) block copolymers (PEG-PLL) were prepared in aqueous milieu, and the water solubility under charge-neutralized (stoichiometric) conditions was maintained. Associates thus prepared achieved remarkable resistance against nuclease attack, probably due to the formation of PEG palisade surrounding the ion-complexed core of the DNA with the PLL segment of the block copolymer. Further, to estimate the stability of the associate… CONTINUE READING

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