Relocalization of Telomeric Ku and SIR Proteins in Response to DNA Strand Breaks in Yeast

Abstract

Telomeric TG-rich repeats and their associated proteins protect the termini of eukaryotic chromosomes from end-to-end fusions. Associated with the cap structure at yeast telomeres is a subtelomeric domain of heterochromatin, containing the silent information regulator (SIR) complex. The Ku70/80 heterodimer (yKu) is associated both with the chromosome end… (More)
DOI: 10.1016/S0092-8674(00)80773-4

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