Reloading of atrophied rat soleus muscle induces tenascin-C expression around damaged muscle fibers.

@article{Flck2003ReloadingOA,
  title={Reloading of atrophied rat soleus muscle induces tenascin-C expression around damaged muscle fibers.},
  author={Martin Fl{\"u}ck and Matthias Chiquet and Silvia Schmutz and Marie-H{\'e}l{\`e}ne Mayet-Sornay and Dominique Desplanches},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2003},
  volume={284 3},
  pages={
          R792-801
        }
}
The hypothesis was tested that mechanical loading, induced by hindlimb suspension and subsequent reloading, affects expression of the basement membrane components tenascin-C and fibronectin in the belly portion of rat soleus muscle. One day of reloading, but not the previous 14 days of hindlimb suspension, led to ectopic accumulation of tenascin-C and an increase of fibronectin in the endomysium of a proportion (8 and 15%) of muscle fibers. Large increases of tenascin-C (40-fold) and… 
View on PubMed
ajpregu.physiology.org
62 Citations
Highly Influential Citations
3
Background Citations
33
Methods Citations
12
Results Citations
2

Figures and Tables from this paper

62 Citations

Transcriptional reprogramming during reloading of atrophied rat soleus muscle.
TLDR
The observations demonstrate that early nuclear reprogramming with reloading of atrophic soleus muscle is coordinated and links to the processes involved in mechanical damage and regeneration of muscle fibers.
Mechanism of Tissue Repair Transcriptional reprogramming during reloading of atrophied rat soleus muscle
TLDR
The observations demonstrate that early nuclear reprogramming with reloading of atrophic soleus muscle is coordinated and links to the processes involved in mechanical damage and regeneration of muscle fibers.
Mechano-regulated Tenascin-C orchestrates muscle repair
TLDR
A TNC-orchestrated molecular pathway integrates muscle repair into the load-dependent control of the striated muscle phenotype and confirms the activation of a complex expression program of interstitial and slow myofiber repair by my ofiber-derived TNC.
Effects of aging on basement membrane of the soleus muscle during recovery following disuse atrophy in rats
Running title : Tenascin-C-deficiency accelerates sarcopenia
TLDR
The results presented here show for the first time that a TNC-orchestrated molecular pathway integrates muscle repair into the load-dependent control of the striated muscle phenotype.
Characteristics of myogenic response and ankle torque recovery after lengthening contraction-induced rat gastrocnemius injury
TLDR
Investigating the temporal and spatial expression patterns of myogenin, myoD, pax7, and myostatin after acute lengthening contraction (LC)-induced injury in the rat hindlimb concluded that myogenic events associate with torque recovery after LC-induced injury.
Mechanotransduction in fibroblasts
TLDR
First microarray-analysis of stretched primary mouse embryo fibroblasts revealed that cells react to biaxial strain by upregulation of a very distinct group of around 30 genes within 1 hour of stretching, suggesting that activation of NfB seem to depend on Ca2+-influx that is mediated by stretch-gated ion-channels in the cell membrane.
Recovery of the soleus muscle after short- and long-term disuse induced by hindlimb unloading: effects on the electrical properties and myosin heavy chain profile
Transcriptional regulation of tenascin genes
TLDR
This article summarizes what is currently known about the complex transcriptional regulation of the 4 tenascin genes in development and disease.
Expression of extracellular matrix components and related growth factors in human tendon and muscle after acute exercise
Acute kicking exercise induces collagen synthesis in both tendon and muscle in humans, but it is not known if this relates to increased collagen transcription and if other matrix genes are regulated.…
...
...

References

SHOWING 1-10 OF 73 REFERENCES
Differential expression of tenascin after denervation, damage or paralysis of mouse soleus muscle
TLDR
The results show that tenascin expression in adult muscles is induced by both axon and muscle fibre damage but not by muscle inactivity, and NCAM, in accordance with previous observations, showed enhanced expression both as a result of inactivity and in association with tissue repair.
Differential response of macrophage subpopulations to soleus muscle reloading after rat hindlimb suspension.
TLDR
Findings indicate that macrophage subpopulations are associated with distinct stages during the recovery process from hindlimb suspension: ED1+ macrophages areassociated with muscle necrosis, whereas ED2+ cells are associatedWith muscle regeneration.
Sarcomere lesion damage occurs mainly in slow fibers of reloaded rat adductor longus muscles.
TLDR
Because active myofiber contractions are requisite for lesion formation, selective recruitment of slow fibers most likely explains their damage susceptibility and atrophy did not explain differential lesion damage across fiber types.
Mechanical loading regulates expression of talin and its mRNA, which are concentrated at myotendinous junctions.
TLDR
Investigation of talin expression in developing and adult muscle and in situ RT-PCR showed that talin and its mRNA are concentrated and colocalized at myotendinous junctions, which indicates that increased mechanical loading promotes talin synthesis, which occurs principally at myotin junctions.
Distribution of fibronectin in normal and regenerating skeletal muscle
TLDR
It is concluded that fibronectin may not be essential for early myogenesis and that regenerated myotubes form an entirely new or at least certain new molecular components of their basement membrane.
Adhesion in skeletal muscle during regteneration
TLDR
Results indicate that regenerating skeletal muscle cells are attached to the ECM in a way that allows both growth of the muscle cells across the scar and their use before the regeneration is completed.
Distinguishing unloading. Versus reloading‐induced changes in rat soleus muscle
TLDR
The degree and type of muscle degenerative changes observed postflight depend on the duration of gravity readaptation before biopsy and not solely on exposure to microgravity.
Tenascin-C expression by fibroblasts is elevated in stressed collagen gels
TLDR
It is proposed that the tenascin-C promoter is directly or indirectly activated in fibroblasts generating and experiencing mechanical stress within a restrained collagen matrix, which may be an important aspect of the regulation of tenascIn-C expression during embryogenesis as well as during wound healing and other regenerative and morphogenetic processes.
Cytoskeletal protein contents before and after hindlimb suspension in a fast and slow rat skeletal muscle.
TLDR
It can be concluded that the cytoskeletal protein expression levels could largely contribute to muscle fiber adaptation induced by modified functional demands.
Tenascin is accumulated along developing peripheral nerves and allows neurite outgrowth in vitro.
TLDR
It is speculated that in vivo tenascin allows axonal outgrowth, but inhibits branching and supports fasciculation of newly formed axons.
...
...