Reloading of atrophied rat soleus muscle induces tenascin-C expression around damaged muscle fibers.

@article{Flck2003ReloadingOA,
  title={Reloading of atrophied rat soleus muscle induces tenascin-C expression around damaged muscle fibers.},
  author={Martin Fl{\"u}ck and Matthias Chiquet and Silvia Schmutz and Marie-H{\'e}l{\`e}ne Mayet-Sornay and Dominique Desplanches},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2003},
  volume={284 3},
  pages={
          R792-801
        }
}
The hypothesis was tested that mechanical loading, induced by hindlimb suspension and subsequent reloading, affects expression of the basement membrane components tenascin-C and fibronectin in the belly portion of rat soleus muscle. One day of reloading, but not the previous 14 days of hindlimb suspension, led to ectopic accumulation of tenascin-C and an increase of fibronectin in the endomysium of a proportion (8 and 15%) of muscle fibers. Large increases of tenascin-C (40-fold) and… 
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The observations demonstrate that early nuclear reprogramming with reloading of atrophic soleus muscle is coordinated and links to the processes involved in mechanical damage and regeneration of muscle fibers.
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The results presented here show for the first time that a TNC-orchestrated molecular pathway integrates muscle repair into the load-dependent control of the striated muscle phenotype.
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