Relics from the RNA World

@article{Jeffares1998RelicsFT,
  title={Relics from the RNA World},
  author={Daniel C. Jeffares and Anthony M. Poole and David Penny},
  journal={Journal of Molecular Evolution},
  year={1998},
  volume={46},
  pages={18-36}
}
Abstract. An RNA world is widely accepted as a probable stage in the early evolution of life. Two implications are that proteins have gradually replaced RNA as the main biological catalysts and that RNA has not taken on any major de novo catalytic function after the evolution of protein synthesis, that is, there is an essentially irreversible series of steps RNA → RNP → protein. This transition, as expected from a consideration of catalytic perfection, is essentially complete for reactions when… 

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Modern mRNA Proofreading and Repair: Clues that the Last Universal Common Ancestor Possessed an RNA Genome?

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References

SHOWING 1-10 OF 157 REFERENCES

The Path from the RNA World

A sequential (step by step) Darwinian model for the evolution of life from the late stages of the RNA world through to the emergence of eukaryotes and prokaryotes, with a functional explanation that proKaryote ancestors underwent selection for thermophily and/or for rapid reproduction at least once in their history.

2 Prospects for Understanding the Origin of the RNA World

The general idea that, in the development of life on the earth, evolution based on RNA replication preceded the appearance of protein synthesis was first proposed about 30 years ago and the existence of an RNA World as a precursor of the authors' DNA/protein world is a hypothesis.

1 Prospects for Understanding the Origin of the RNA World

The existence of an RNA world as a precursor of the authors' DNA/protein world is a hypothesis and three basic assumptions are included: At some time in the evolution of life, genetic continuity was assured by the replication of RNA; Watson-Crick base-pairing was the key to replication; and genetically encoded proteins were not involved as catalysts.

On the origin of the ribosome Coevolution of subdomains of tRNA and rRNA

Adherents of RNA world scenarios imagine that something resembling protein synthesis was carried out by ribozyme-like protoribosomes prior to the advent of ribosomal proteins and translation factors (not to mention aminoacyl-tRNA synthetases).

8 On the Origin of the Ribosome: Coevolution of Subdomains of tRNA and rRNA

Adherents of RNA World scenarios imagine, to varying degrees, that something resembling protein synthesis was carried out by ribozyme-like proto-ribosomes prior to the advent of ribosomal proteins and translation factors (not to mention aminoacyl-tRNA synthetases), which solve the chicken-or-the-egg problem of the molecular evolution of Ribosomes but raise some difficult new questions.

Were RNA replication and translation directly coupled in the RNA (+protein?) World?

  • K. Gordon
  • Biology
    Journal of theoretical biology
  • 1995
Coupling of reversible RNA replication by transesterification with the thermodynamically favourable process of transpeptidation provides a rationale for the evolution of the complete ribosome as a replicase for large RNAs in the RNA (+protein?) world.

Template switching between PNA and RNA oligonucleotides

It is shown that RNA oligonucleotides facilitate the synthesis of complementary PNA strands and vice versa, which suggests that a transition between different genetic systems can occur without loss of information.

RNA processing in prokaryotic cells

  • D. ApirionA. Miczak
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 1993
RNase III, RNase E and RNase P are responsible for most of the primary endonucleolytic RNA processing events, and it seems that only in secondary RNA processing is the RNP particle required for the reaction.

Interactions of a small RNA with antibiotic and RNA ligands of the 30S subunit

It is reported here that an oligo-ribonucleotide analogue of the decoding region interacts with both antibiotic and RNA ligands of the 30S subunit in a manner that correlates with normal subunit function, suggesting that the intimidating structural complexity of the ribosome can be circumvented.

The genomic tag hypothesis: modern viruses as molecular fossils of ancient strategies for genomic replication, and clues regarding the origin of protein synthesis.

Although tRNA is best known as a component of the translation apparatus, tRNA and tRNA-like molecules also play key roles-either as template or as primer-in a wide variety of replicative processes.
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