Reliable prediction of Drosha processing sites improves microRNA gene prediction

@article{Helvik2007ReliablePO,
  title={Reliable prediction of Drosha processing sites improves microRNA gene prediction},
  author={Snorre A. Helvik and Ola R. Sn\ove and P{\aa}l S{\ae}trom},
  journal={Bioinformatics},
  year={2007},
  volume={23 2},
  pages={142-9}
}
MOTIVATION Mature microRNAs (miRNAs) are processed from long hairpin transcripts. Even though it is only the first of several steps, the initial Drosha processing defines the mature product and is characteristic for all miRNA genes. Methods that can separate between true and false processing sites are therefore essential to miRNA gene discovery. RESULTS We present a classifier that predicts 5' Drosha processing sites in hairpins that are candidate miRNAs. The classifier, called Microprocessor… CONTINUE READING
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