Reliable and efficient procedures for the conjugation of biomolecules through Huisgen azide-alkyne cycloadditions.

@article{Lallana2011ReliableAE,
  title={Reliable and efficient procedures for the conjugation of biomolecules through Huisgen azide-alkyne cycloadditions.},
  author={Enrique Lallana and Ricardo Riguera and Eduardo Fernandez-Megia},
  journal={Angewandte Chemie},
  year={2011},
  volume={50 38},
  pages={8794-804}
}
The Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) has been established as a powerful coupling technology for the conjugation of proteins, nucleic acids, and polysaccharides. Nevertheless, several shortcomings related to the presence of Cu, mainly oxidative degradation by reactive oxygen species and sample contamination by Cu, have been pointed out. This Minireview discusses key aspects found in the development of the efficient and benign functionalization of biomacromolecules through CuAAC… CONTINUE READING
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