Reliability of antimalarial sensitivity tests depends on drug mechanisms of action.

@article{Wein2010ReliabilityOA,
  title={Reliability of antimalarial sensitivity tests depends on drug mechanisms of action.},
  author={Sharon Wein and Marjorie Maynadier and Christophe Tran van Ba and Rachel Cerdan and Suzanne Peyrottes and Laurent Fraisse and Henri J. Vial},
  journal={Journal of clinical microbiology},
  year={2010},
  volume={48 5},
  pages={1651-60}
}
In vitro antimalarial activity tests play a pivotal role in malaria drug research or for monitoring drug resistance in field isolates. We applied two isotopic tests, two enzyme-linked immunosorbent assays (ELISA) and the SYBR green I fluorescence-based assay, to test artesunate and chloroquine, the metabolic inhibitors atovaquone and pyrimethamine, our fast-acting choline analog T3/SAR97276, and doxycycline, which has a delayed death profile. Isotopic tests based on hypoxanthine and… CONTINUE READING