Reliability in the Identification of Midbrain Dopamine Neurons

  title={Reliability in the Identification of Midbrain Dopamine Neurons},
  author={Elyssa B. Margolis and Allison R. Coker and Joseph R. Driscoll and Anne-Iris Lema{\^i}tre and Howard L Fields},
  booktitle={PloS one},
Brain regions typically contain intermixed subpopulations of neurons with different connectivity and neurotransmitters. This complicates identification of neuronal phenotypes in electrophysiological experiments without using direct detection of unique molecular markers. A prime example of this difficulty is the identification of dopamine (DA) neurons in the midbrain ventral tegmental area (VTA). Although immunocytochemistry (ICC) against tyrosine hydroxylase (TH) is widely used to identify DA… CONTINUE READING


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