Reliability and validity of the International Cooperative Ataxia Rating Scale: A study in 156 spinocerebellar ataxia patients
@article{SchmitzHbsch2006ReliabilityAV, title={Reliability and validity of the International Cooperative Ataxia Rating Scale: A study in 156 spinocerebellar ataxia patients}, author={Tanja Schmitz-H{\"u}bsch and Sophie Tezenas du Montcel and L{\'a}szl{\'o} Balik{\'o} and Sylvia Boesch and Sara Bonato and Roberto Fancellu and Paola Giunti and Christoph Globas and Jun-Suk Kang and B Kremer and Caterina Mariotti and B{\'e}la Melegh and Maryla Rakowicz and Rafał Rola and Sylvie Romano and L. Sch{\"o}ls and Sandra Szymanski and Bart P.C. Van de Warrenburg and Elzbieta Zdzienicka and Alexandra D{\"u}rr and Thomas Klockgether}, journal={Movement Disorders}, year={2006}, volume={21} }
To evaluate the efficacy of treatments in spinocerebellar ataxias (SCAs), appropriate clinical scales are required. This study evaluated metric properties of the International Cooperative Ataxia Rating Scale (ICARS) in 156 SCA patients and 8 controls. ICARS was found to be a reliable scale satisfying accepted criteria for interrater reliability, test–retest reliability, and internal consistency. Although validity testing was limited, we found evidence of validity of ICARS when ataxia disease…
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References
SHOWING 1-10 OF 18 REFERENCES
International Cooperative Ataxia Rating Scale for pharmacological assessment of the cerebellar syndrome
- Psychology, MedicineJournal of the Neurological Sciences
- 1997
Inter‐rater reliability of the International Cooperative Ataxia Rating Scale (ICARS)
- Psychology, MedicineMovement disorders : official journal of the Movement Disorder Society
- 2004
The ICARS exhibits very high inter‐rater reliability even without prior observer standardisation and is sensitive to a range of ataxia severities from very mild to severe.
Application of the International Cooperative Ataxia Scale rating in multiple system atrophy
- Psychology, MedicineMovement disorders : official journal of the Movement Disorder Society
- 2002
The ICARS appears a useful tool to extract and rate the severity of cerebellar signs in MSA; however, it is clearly contaminated by parkinsonian features.
Eyeblink conditioning in patients with hereditary ataxia: a one-year follow-up study
- Psychology, BiologyExperimental Brain Research
- 2004
Impaired learning of conditioned eyeblink responses is a stable finding across multiple sessions in patients with degenerative cerebellar disorders, indicating that eyeblink conditioning may be a useful measure of Cerebellar impairment in patientsWith hereditary ataxias that primarily affect the cerebellum, extracerebellar involvement not assessed by ICARS likely contributes to eyeb link conditioning abnormalities.
The natural history of degenerative ataxia: a retrospective study in 466 patients.
- Biology, MedicineBrain : a journal of neurology
- 1998
In FRDA, the time until confinement to wheelchair was shorter in patients with earlier disease onset, suggesting that patients with long GAA repeats and early disease onset have a poor prognosis, and in MSA, later age of onset increased the risk of rapid progression and death.
Effects of the oral form of ondansetron on cerebellar dysfunction
- Medicine, PsychologyJournal of Neurology
- 2003
The analysis by subgroups showed that the oral form of ondansetron is deleterious for coordination in patients with CCA, has no effect upon tremor in upper limbs, and has a mild effect upon posture and coordination in lower limbs in some subgroups of ataxic diseases.
Friedreich's ataxia: idebenone treatment in early stage patients.
- Medicine, PsychologyNeuropediatrics
- 2002
Idebenone treatment at early stages of the disease seems to reduce the progression of cerebellar manifestations and further blind trials with a greater number of patients and higher doses are needed to fully assess the therapeutic potential of idebenone in Friedreich's ataxia.
Autosomal dominant cerebellar ataxias: clinical features, genetics, and pathogenesis
- Medicine, PsychologyThe Lancet Neurology
- 2004
Clinical and genetic aspects of spinocerebellar degeneration
- Biology, MedicineCurrent opinion in neurology
- 2000
Unexpectedly, the genes responsible for Friedreich's ataxia and a form of autosomal recessive spastic paraplegia place these diseases in the category of mitochondrial disorders.
Tremor and ataxia in fragile X premutation carriers: Blinded videotape study
- MedicineAnnals of neurology
- 2003
The F MR1 premutation is associated with increased levels of CGG repeat‐containing FMR1 mRNA, which may predispose to these symptoms by interfering with nuclear mechanisms, and this mutation may be a significant cause of late‐onset “idiopathic” progressive tremor.