Relevant use of Klotho in FGF19 subfamily signaling system in vivo.

  title={Relevant use of Klotho in FGF19 subfamily signaling system in vivo.},
  author={Ken-ichi Tomiyama and Ryota Maeda and Itaru Urakawa and Yuji Yamazaki and Tomohiro Tanaka and Shinji Ito and Yoko Nabeshima and Tsutomu Tomita and Shinji Odori and Kiminori Hosoda and Kazuwa Nakao and Akihiro Imura and Yo-ichi Nabeshima},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 4},
Alpha-Klotho (alpha-Kl) and its homolog, beta-Klotho (beta-Kl) are key regulators of mineral homeostasis and bile acid/cholesterol metabolism, respectively. FGF15/ humanFGF19, FGF21, and FGF23, members of the FGF19 subfamily, are believed to act as circulating metabolic regulators. Analyses of functional interactions between alpha- and beta-Kl and FGF19 factors in wild-type, alpha-kl(-/-), and beta-kl(-/-) mice revealed a comprehensive regulatory scheme of mineral homeostasis involving the… CONTINUE READING


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