Relevance of xenobiotic enzymes in human skin in vitro models to activate pro-sensitizers.

@article{Jaeckh2012RelevanceOX,
  title={Relevance of xenobiotic enzymes in human skin in vitro models to activate pro-sensitizers.},
  author={Christine Jaeckh and Eric J. Fabian and Bennard van Ravenzwaay and Robert Landsiedel},
  journal={Journal of immunotoxicology},
  year={2012},
  volume={9 4},
  pages={426-38}
}
Skin exposure to sensitizing chemicals can induce allergic reactions. Certain chemicals, so called pro-sensitizers, need metabolic activation to become allergenic. Their metabolic activation occurs in skin cells such as keratinocytes or dendritic cells. These cell types are also incorporated into dermal in vitro test systems used to assess the sensitizing potential of chemicals for humans. In vitrosystems range from single cell cultures to organotypic multi-cellular reconstructed skin models… CONTINUE READING