Relevance of the quantification of apolipoprotein E in the cerebrospinal fluid in Alzheimer's disease

@article{Lefranc1996RelevanceOT,
  title={Relevance of the quantification of apolipoprotein E in the cerebrospinal fluid in Alzheimer's disease},
  author={Didier Lefranc and Patrick Vermersch and Jean Dallongeville and Christine Daems-Monpeurt and Andr{\'e} Delacourte},
  journal={Neuroscience Letters},
  year={1996},
  volume={212},
  pages={91-94}
}
  • Didier Lefranc, Patrick Vermersch, +2 authors André Delacourte
  • Published in Neuroscience Letters 1996
  • Medicine, Biology
  • Apolipoprotein E (Apo E), one of the major structural and functional apolipoproteins, has recently been implicated in the pathogenesis of Alzheimer's disease (AD). Several studies revealed that Apo E4 isoform is associated with the pathogenic process in AD. A significant reduction of cerebrospinal fluid (CSF) Apo E level in AD patients has been reported in two studies. To further investigate the physiopathological significance of such a variation of Apo E concentration in the CSF, we performed… CONTINUE READING

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