Relevance of studying T cell responses in SIV-infected rhesus macaques.

@article{Valentine2008RelevanceOS,
  title={Relevance of studying T cell responses in SIV-infected rhesus macaques.},
  author={Laura E. Valentine and David I. Watkins},
  journal={Trends in microbiology},
  year={2008},
  volume={16 12},
  pages={605-11}
}
HIV infection, once established, is never cleared. Rare individuals do, however, control viral replication to low levels. These successful immune responses are primarily linked to certain class I MHC alleles (MHC-I). Because of this association, many AIDS vaccines in development are designed to generate virus-specific CD8+ T cells. The Merck STEP phase 2b efficacy trial of one such vaccine was recently halted, and declared a failure. Thus, basic questions regarding what constitutes an effective… CONTINUE READING
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Nonhuman primatemodels and the failure of the Merck HIV-1 vaccine in humans

  • Watkins, D.I
  • Nat. Med
  • 2008

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