Relevance of rat liver tumors to human hepatic and endometrial cancer.

@article{Guzelian1997RelevanceOR,
  title={Relevance of rat liver tumors to human hepatic and endometrial cancer.},
  author={Philip S. Guzelian},
  journal={Seminars in oncology},
  year={1997},
  volume={24 1 Suppl 1},
  pages={S1-105-S1-21}
}
Concern for a risk of cancer in humans has been prompted by the appearance of hepatocellular carcinomas in tamoxifen-treated rats. However, there is no evidence of excess hepatocellular carcinoma among tamoxifen-treated women. Moreover, liver tumors are not induced in tamoxifen-treated mice or hamsters. An explanation for the species selectivity of this… CONTINUE READING