Relevance of presenting white blood cell count and kinetics of molecular remission in the prognosis of acute myeloid leukemia with CBFbeta/MYH11 rearrangement.

@article{Martn2000RelevanceOP,
  title={Relevance of presenting white blood cell count and kinetics of molecular remission in the prognosis of acute myeloid leukemia with CBFbeta/MYH11 rearrangement.},
  author={Guillermo Mart{\'i}n and Eva Barrag{\'a}n and Pascual Bolufer and Carmen Chill{\'o}n and Ram{\'o}n Garc{\'i}a-Sanz and Teresita Gomez and Salut Brunet and M G Gonz{\'a}lez and Miguel Angel Sanz},
  journal={Haematologica},
  year={2000},
  volume={85 7},
  pages={699-703}
}
BACKGROUND AND OBJECTIVES The detection of CBFbeta/MYH11 transcripts by RT-PCR has became a valuable and widely used technique in the accurate cytogenetic and molecular classification of acute myeloid leukemia (AML), but the clinical value of RT-PCR for monitoring minimal residual disease (MRD) during follow-up remains unclear. DESIGN AND METHODS We analyzed the factors predicting relapse and the value of MRD monitoring by RT-PCR in a series of 16 patients with CBFb/MYH11-positive AML (15… CONTINUE READING