Relevance of platelet factor four (PF4) plasma levels in multiple sclerosis.

  title={Relevance of platelet factor four (PF4) plasma levels in multiple sclerosis.},
  author={A R Cananzi and F Ferro-Milone and Francesco A Grigoletto and M Toldo and Francesca Meneghini and F Bortolon and Giovanni D'Andrea},
  journal={Acta neurologica Scandinavica},
  volume={76 2},
In order to study the role of platelets in Multiple Sclerosis (MS) we assessed, in a group of patients during a quiescent phase of the disease, the plasma levels of beta-thromboglobulin (beta-TG) and platelet factor four (PF4) both in absence of treatment and during administration of aspirin (ASA) at the dose of 50 mg/daily. In the MS patients studied, the basal plasma levels of beta-TG and PF4 were significantly higher than in control subjects. The increase in the beta-TG plasma levels… CONTINUE READING