Relevance of plasmid pKM101-mediated mutagenicity in bacteria to genotoxicity in mammalian cells.

@article{Little1989RelevanceOP,
  title={Relevance of plasmid pKM101-mediated mutagenicity in bacteria to genotoxicity in mammalian cells.},
  author={Craig A. Little and David J Tweats and R. J. Pinney},
  journal={Mutagenesis},
  year={1989},
  volume={4 5},
  pages={
          371-6
        }
}
Three structurally related compounds, 4-acetoxy-3-acetoxy-methyl-acetophenone (AAMAP), 1-[4'-hydroxy-3'-hydroxy-methylphenyl]-2-[benzyl-t-butylamino] ethanone hydrochloride (HHBEH) and 1-[4'-hydroxy-3'-hydroxymethyl-phenyl]-2-[benzyl-t-butylamino] ethanol (HHBE), gave positive dose-related mutagenic responses in the Ames test when Salmonella typhimurium strain TA100 was used as the test organism. Strain TA100 carries the hisG46 allele, which is revertable by base changes, together with plasmid… 
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