Relevance of plasmid pKM101-mediated mutagenicity in bacteria to genotoxicity in mammalian cells.

  title={Relevance of plasmid pKM101-mediated mutagenicity in bacteria to genotoxicity in mammalian cells.},
  author={Craig A. Little and David J Tweats and R. J. Pinney},
  volume={4 5},
Three structurally related compounds, 4-acetoxy-3-acetoxy-methyl-acetophenone (AAMAP), 1-[4'-hydroxy-3'-hydroxy-methylphenyl]-2-[benzyl-t-butylamino] ethanone hydrochloride (HHBEH) and 1-[4'-hydroxy-3'-hydroxymethyl-phenyl]-2-[benzyl-t-butylamino] ethanol (HHBE), gave positive dose-related mutagenic responses in the Ames test when Salmonella typhimurium strain TA100 was used as the test organism. Strain TA100 carries the hisG46 allele, which is revertable by base changes, together with plasmid… 
Genotoxicity of pyrroloquinoline quinone (PQQ) disodium salt (BioPQQ™).
Spectra of spontaneous frameshift mutations at the hisD3052 allele of Salmonella typhimurium in four DNA repair backgrounds.
All spontaneous mutations of the hisD3052 allele are likely templated, and the mechanisms may involve the potential of direct and inverted repeats to undergo slippage and misalignment and to form quasi-palindromes and the interaction of these sequences with DNA replication and repair proteins.
Simultaneous Analysis of P53 Protein Expression and Cell Proliferation in Irradiated Human Lymphocytes by Flow Cytometry
It was verified a reduction in the proliferation rate of irradiated lymphocytes and a rise in the p53 expression levels, similar for quiescent and proliferating lymphocytes, which emphasize the importance of the use of CFSE-stained lymphocytes in assays associated to proliferation rate.
Living Organisms Author Their Read-Write Genomes in Evolution
The intersections of cell activities, biosphere interactions, horizontal DNA transfers, and non-random Read-Write genome modifications by natural genetic engineering provide a rich molecular and biological foundation for understanding how ecological disruptions can stimulate productive, often abrupt, evolutionary transformations.