Relevance of oxidative pathways in the pathophysiology of chronic kidney disease.

  title={Relevance of oxidative pathways in the pathophysiology of chronic kidney disease.},
  author={Jonathan Himmelfarb},
  journal={Cardiology clinics},
  volume={23 3},
Patients with uremia (whether requiring renal replacement therapy or not) have a greatly increased cardiovascular risk that cannot be explained entirely by traditional cardiovascular risk factors. An increase in oxidative stress has been proposed as a nontraditional cardiovascular risk factor in this patient population. Using a wide variety of different biomarkers of increased oxidative stress status, numerous laboratories around the world have now unequivocally demonstrated that uremia is a… CONTINUE READING


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