Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells.

@article{Squires2003RelevanceOM,
  title={Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells.},
  author={Matthew S. Squires and Eric A. Hudson and Lynne Howells and Stewart Sale and Catherine Houghton and Janet Louise Jones and Louise H Fox and Martin Dickens and Sally A. Prigent and Margaret M. Manson},
  journal={Biochemical pharmacology},
  year={2003},
  volume={65 3},
  pages={361-76}
}
Following observations that curcumin inhibited proliferation (IC(50)=1-5 microM), invasiveness and progression through S/G2/M phases of the cell cycle in the non-tumourigenic HBL100 and tumourigenic MDA-MB-468 human breast cell lines, it was noted that apoptosis was much more pronounced in the tumour line. Therefore, the ability of curcumin to modulate signalling pathways which might contribute to cell survival was investigated. After pre-treatment of cells for 20 min, curcumin (40 microM… CONTINUE READING

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