Relevance of interleukin-1 receptor antagonist intron-2 polymorphism in ischemic stroke.

@article{Seripa2003RelevanceOI,
  title={Relevance of interleukin-1 receptor antagonist intron-2 polymorphism in ischemic stroke.},
  author={Davide Seripa and Aldo Dobrina and Maurizio Margaglione and Maria Giovanna Matera and Carolina Gravina and Elena Vecile and Vito Michele Fazio},
  journal={Cerebrovascular diseases},
  year={2003},
  volume={15 4},
  pages={276-81}
}
Evidence of inflammatory phenomena associated with atherosclerotic plaques is extensive. Interleukin-1 (IL-1) is one of the key modulators of the inflammatory response, and its activity is critically regulated by its receptor antagonist (IL-1Ra). A variable number of tandem repeats (VNTR) in intron 2 of the human IL-1Ra shows a common polymorphism that has been related to different production of IL-1Ra and IL-1 proteins. In monocytes, the less common allele 2 has been associated with an… CONTINUE READING

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