Relevance of hypointense brain MRI lesions for long-term worsening of clinical disability in relapsing multiple sclerosis.

@article{Giorgio2014RelevanceOH,
  title={Relevance of hypointense brain MRI lesions for long-term worsening of clinical disability in relapsing multiple sclerosis.},
  author={Antonio Di Giorgio and Maria Laura Stromillo and Maria Letizia Bartolozzi and Francesca Rossi and Marco Battaglini and Alessandro De Leucio and Leonello Guidi and Patrizia Maritato and Emilio Portaccio and Maria Pia Sormani and Maria Pia Amato and Nicola De Stefano},
  journal={Multiple sclerosis},
  year={2014},
  volume={20 2},
  pages={
          214-9
        }
}
BACKGROUND The accrual of brain focal pathology is considered a good substrate of disability in relapsing-remitting multiple sclerosis (RRMS). However, knowledge on long-term lesion evolution and its relationship with disability progression is poor. OBJECTIVE The objective of this paper is to evaluate in RRMS the long-term clinical relevance of brain lesion evolution. METHODS In 58 RRMS patients we acquired, using the same scanner and protocol, brain magnetic resonance imaging (MRI) at… CONTINUE READING
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